Looks fun, though for that price, I'd normally expect a power supply included (and no assembly required). Acrylic costs more than sheet metal though.
It's actually easy to work with, if you want to modify it any. The trick is to cut/drill it by heat not mechanical stress. Stressing it can crack it and ruin the whole thing. If you need to drill a hole, run the drill in reverse, and slowly melt a hole through. If you need to cut, use masonry or metal grinding blades. You can even bend it, if you have a way to apply the right amount of heat in a thin, straight strip along it.
Definitely spray-paint internal components! Take care to do a good job of it, and it'll be pretty awesome. You'll have people wondering where in the world you found a metallic green hard drive. For best quality, try using the large-area auto body touch-up systems. They'll be expensive, but you don't need much, and they're very well suited to putting high-quality finishes on metal parts. You can take another cue from auto-painters by covering up surfaces you don't want to paint with (anti-static!) plastic sheets. That way, you can paint that hard drive/whatever without worrying about what painting over the circuit boards might do.
For lighting, you might try something more subtle, that would only work with acrylic. You might shine lights into the feet or edges of the case, to make the light travel lengthwise through the acrylic, making for a cool effect of light coming from the case itself, not from any visible source. If you combine that with etching the surface of the acrylic, the etchings should glow, again with no visible source.
It's looks pretty awesome, certainly something different. I might be a little worried about durability with scratching and cracking, but if you're wanting to customize the case I think that makes up for durability concerns.
DO NOT go acrylic... I used the same case in the pictures above and it was a PoS.
It scratched up so easily, the little metal stobs that hold the screws in the plastic come out all the time, when it gets so much as 1 peice of dust on it starts to look like doodey. It's not very solid at all.
I used it for 2 years, I ended up going with the antec 900 now. I'm much more pleased.
I would only use an acrylic case for:
1) A showcase computer that would not be ran very much (or touched).
2) For a client that wanted an acrylic case in spite of everything I told them.